Anti-Dact2 antibody (ab79042)
Key features and details
- Rabbit polyclonal to Dact2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Dact2 antibody -
Description
Rabbit polyclonal to Dact2 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
A 12 amino acid synthetic peptide from near the amino terminus of human Dact2 (NP_999627).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab79042 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa.
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ICC/IF |
Use a concentration of 20 µg/ml.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa. |
ICC/IF
Use a concentration of 20 µg/ml. |
Target
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Function
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. -
Sequence similarities
Belongs to the dapper family. -
Domain
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. - Information by UniProt
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Database links
- Entrez Gene: 168002 Human
- Omim: 608966 Human
- SwissProt: Q5SW24 Human
- Unigene: 673059 Human
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Alternative names
- bA503C24.7 antibody
- C6orf116 antibody
- Chromosome 6 open reading frame 116 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab79042 has been referenced in 4 publications.
- Wang Y et al. miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis. Mol Ther Nucleic Acids 24:610-621 (2021). PubMed: 33898109
- Guo L et al. Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway. Oncol Lett 15:3287-3294 (2018). PubMed: 29435071
- Guo YL et al. Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. J Biomed Sci 24:6 (2017). IHC-P ; Human . PubMed: 28077137
- Hou J et al. DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma. Cancer Prev Res (Phila) 6:791-800 (2013). PubMed: 23803417