Stable inhibitor of EGF receptor-associated tyrosine in vitro ((IC50 = 0.15 µg/ml). Inhibition is competitive with substrate and noncompetitive with ATP. Approximately 4 times more stable than Erbstatin in calf serum. Shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of DNA synthesis.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Komura N et al. Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells. Exp Cell Res313:2753-65 (2007).
Read more (PubMed: 17585903) »
Koch JA et al. Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells. Biochem Biophys Res Commun225:531-6 (1996).
Read more (PubMed: 8753796) »
Azuma Y et al. Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins. Cell Immunol152:271-8 (1993).
Read more (PubMed: 8242767) »
Umezawa K et al. Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells. FEBS Lett314:289-92 (1992).
Read more (PubMed: 1468560) »
Umezawa K et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett260:198-200 (1990).
Read more (PubMed: 2298299) »