Overview

  • Product name

  • Description

    Goat polyclonal to FBP17
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide,

    KQLESSKRRFERDC

    , corresponding to internal sequence amino acids 132-145 of Human FBP17

  • Positive control

    • Human Small Intestine and Human Tonsil tissue Human testis lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.25 - 2 µg/ml. Predicted molecular weight: 71 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function

    May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
  • Tissue specificity

    Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
  • Involvement in disease

    Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
  • Sequence similarities

    Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
  • Information by UniProt
  • Database links

  • Alternative names

    • FBP1 antibody
    • FBP17 antibody
    • Fnbp1 antibody
    • FNBP1_HUMAN antibody
    • Formin binding protein 1 antibody
    • Formin binding protein 17 antibody
    • Formin-binding protein 1 antibody
    • Formin-binding protein 17 antibody
    • hFBP17 antibody
    • KIAA0554 antibody
    • MGC126804 antibody
    see all

Images

  • Immunohistochemical staining of Human Small Intestine using ab113961 at 3.75µg/ml
  • Immunohistochemical staining of Human Tonsil using ab113961 at 3.75µg/ml
  • Anti-FBP17 antibody (ab113961) at 0.25 µg/ml + Human testis lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 71 kDa



    Primary incubated for 1 hour.

References

ab113961 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

Merci beaucoup pour votre message et pour cette information.

J'ai mis à jour le système afin que l'anti-FBP17 ab113961 ne soit plus marqué comme étant problématique.

Bonne continuation dans vos travaux de recherche, n'hésitez pas à nous contacter de nouveau si nécessaire.

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Answer

Comme convenu par téléphone je serai ravi de demander au service financier d'Abcam d'éditer un avoir ou de procéder à un échange avec une unité d'anti-tubuline.

En échange, nous serions ravis si vous pouviez nous communiquer quelques détails concernant votre protocole en remplissant le questionnaire ci-joint. Ces informations sont très importantes pour nous car elles nous permettent d'investiguer la source du problème rencontré avec l'anticorps ab113961 et de prendre les dispositions nécessaires pour assurer une bonne qualité de nos produits.

Je vous remercie par avance de nous envoyer votre protocole.

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