Overview

  • Product name

  • Description

    Goat polyclonal to FBP17
  • Host species

    Goat
  • Tested applications

    Suitable for: ELISA, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Zebrafish
  • Immunogen

    Synthetic peptide:

    KQLESSKRRFERDC

    , corresponding to amino acids 132 - 145 of Human FBP17.

  • Positive control

    • Human Testis lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab23934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: 1/32000.
    WB: Use at a concentration of 0.25 - 2.0 µg/ml. Predicted molecular weight: 70 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
    • Tissue specificity

      Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
    • Involvement in disease

      Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
    • Sequence similarities

      Belongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • Cellular localization

      Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
    • Information by UniProt
    • Database links

    • Alternative names

      • FBP1 antibody
      • FBP17 antibody
      • Fnbp1 antibody
      • FNBP1_HUMAN antibody
      • Formin binding protein 1 antibody
      • Formin binding protein 17 antibody
      • Formin-binding protein 1 antibody
      • Formin-binding protein 17 antibody
      • hFBP17 antibody
      • KIAA0554 antibody
      • MGC126804 antibody
      see all

    Images

    • Anti-FBP17 antibody (ab23934) at 0.25 µg/ml + Human Testis lysate (RIPA buffer, 35µg total protein per lane).

      Predicted band size: 70 kDa
      Observed band size: 70 kDa



      Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

    References

    ab23934 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab23934.
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