Anti-FGFR4 antibody (ab119378)
Key features and details
- Rabbit polyclonal to FGFR4
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-FGFR4 antibody
See all FGFR4 primary antibodies -
Description
Rabbit polyclonal to FGFR4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Synthetic peptide conjugated to KLH, surrounding amino acids 45-49 (L-T-V-A-L) of Human FGFR4.
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Positive control
- Rat liver and brain tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab119378 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 88 kDa).
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 88 kDa). |
Target
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Function
Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19. -
Tissue specificity
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Post-translational
modificationsGlycosylated.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization. -
Cellular localization
Membrane. Isoform 2 may be secreted. - Information by UniProt
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Database links
- Entrez Gene: 25114 Rat
- SwissProt: Q498D6 Rat
- Unigene: 24104 Rat
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Alternative names
- CD 334 antibody
- CD334 antibody
- CD334 antigen antibody
see all
Images
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All lanes : Anti-FGFR4 antibody (ab119378) at 1/500 dilution
Lane 1 : Rat liver lysate
Lane 2 : Rat brain lysate
Predicted band size: 88 kDa
Observed band size: 110 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab119378 has been referenced in 5 publications.
- Chen RA et al. Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition. mSystems 7:e0017222 (2022). PubMed: 35670534
- Li H et al. Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis. Nutr Metab (Lond) 17:34 (2020). PubMed: 32377219
- Lee KW et al. FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPAR? regulators. FEBS Open Bio 9:769-780 (2019). PubMed: 30984550
- Erstad DJ et al. Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist. Hepatol Commun 2:821-835 (2018). PubMed: 30027140
- Romain G et al. Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis. BMC Microbiol 13:238 (2013). WB ; Mouse . PubMed: 24165751