Anti-FGFRL1 antibody (ab95940)
Key features and details
- Rabbit polyclonal to FGFRL1
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-FGFRL1 antibody -
Description
Rabbit polyclonal to FGFRL1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 150 - 486 of Human FGFRL1
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab95940 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 55 kDa.
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IHC-P |
1/100 - 1/250.
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ICC/IF |
Use at an assay dependent concentration.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 55 kDa. |
IHC-P
1/100 - 1/250. |
ICC/IF
Use at an assay dependent concentration. |
Target
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Function
Has a negative effect on cell proliferation. -
Tissue specificity
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. -
Sequence similarities
Contains 3 Ig-like C2-type (immunoglobulin-like) domains. -
Cellular localization
Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. - Information by UniProt
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Database links
- Entrez Gene: 53834 Human
- Entrez Gene: 116701 Mouse
- Entrez Gene: 360903 Rat
- Omim: 605830 Human
- SwissProt: Q8N441 Human
- SwissProt: Q91V87 Mouse
- SwissProt: Q7TQM3 Rat
- Unigene: 193326 Human
see all -
Alternative names
- FGF homologous factor receptor antibody
- FGF receptor like protein 1 antibody
- FGF receptor-like protein 1 antibody
see all
Images
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All lanes : Anti-FGFRL1 antibody (ab95940) at 1/1000 dilution
Lane 1 : 293T whole cell lysate
Lane 2 : HepG2 whole cell lysate
Lane 3 : Raji whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 55 kDa
10% SDS PAGE -
ab95940, at a 1/100 dilution, staining FGFRL1 in paraffin-embedded Oral CA Cal27 by Immunohistochemical analysis.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab95940 has been referenced in 7 publications.
- Duan XH et al. HuR affects chemoresistance of small cell lung cancer by regulating FGFRL1 expression. Exp Ther Med 24:638 (2022). PubMed: 36160905
- Maehara O et al. FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma. Cancer Biol Ther 22:372-380 (2021). PubMed: 34224333
- Du Y et al. A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1a and p53 activity in triple-negative breast cancer. Cell Death Dis 11:731 (2020). PubMed: 32908121
- Fan Y et al. Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Biosci Rep 40:N/A (2020). PubMed: 31919528
- Siegfried JM et al. Interaction between the estrogen receptor and fibroblast growth factor receptor pathways in non-small cell lung cancer. Oncotarget 8:24063-24076 (2017). WB . PubMed: 28445992
- Cha YJ et al. MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis. Prostate 76:937-47 (2016). PubMed: 27017949
- di Martino E et al. An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer. Genes Chromosomes Cancer N/A:N/A (2013). PubMed: 23775577