Anti-GPCR GPR43 antibody (ab124272)
Key features and details
- Rabbit polyclonal to GPCR GPR43
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human, African green monkey
- Isotype: IgG
Overview
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Product name
Anti-GPCR GPR43 antibody
See all GPCR GPR43 primary antibodies -
Description
Rabbit polyclonal to GPCR GPR43 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human, African green monkey -
Immunogen
Synthetic peptide conjugated to KLH, corresponding to the C terminal region of Human GPCR GPR43.
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Positive control
- Human tonsil tissue; COS7 cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine), 49% PBS
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab124272 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml.
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ICC/IF |
1/100 - 1/500.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. |
ICC/IF
1/100 - 1/500. |
Target
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Function
Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. -
Tissue specificity
Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2867 Human
- Omim: 603823 Human
- SwissProt: O15552 Human
- Unigene: 248056 Human
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Alternative names
- Fatty acid receptor 2 antibody
- FFA2R antibody
- Ffar2 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab124272 has been referenced in 3 publications.
- Frei R et al. Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils. J Leukoc Biol 109:741-751 (2021). PubMed: 32803826
- Matsuya-Ogawa M et al. Oncoprotective Effects of Short-Chain Fatty Acids on Uterine Cervical Neoplasia. Nutr Cancer 71:312-319 (2019). PubMed: 30836015
- Pan P et al. Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. Carcinogenesis 38:86-93 (2017). PubMed: 27866157