GSK-J4, histone demethylase JMJD3/UTX inhibitor (ab144395)
Key features and details
- Cell permeable histone demethylase JMJD3/UTX inhibitor
- CAS Number: 1373423-53-0
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK-J4, histone demethylase JMJD3/UTX inhibitor -
Description
Cell permeable histone demethylase JMJD3/UTX inhibitor -
Alternative names
- Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
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Purity
> 98% -
CAS Number
1373423-53-0 -
Chemical structure
Properties
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Chemical name
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester -
Molecular weight
417.51 -
Molecular formula
C24H27N5O2 -
PubChem identifier
71729974 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4.Cl -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab144395 has been referenced in 6 publications.
- Gao Y et al. JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation. Environ Toxicol 38:754-769 (2023). PubMed: 36537648
- Gao Y et al. H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury. Cell Death Discov 8:475 (2022). PubMed: 36456564
- Sun J et al. microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-?B signaling pathway. Stem Cell Res Ther 12:14 (2021). PubMed: 33413595
- Yamada T et al. Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol 202:1088-1098 (2019). PubMed: 30626691
- Zhang YX et al. The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory. Neuropharmacology 141:113-125 (2018). PubMed: 30165076
- Watarai H et al. Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin. Anticancer Res 36:6083-6092 (2016). PubMed: 27793936