Anti-HRG beta 1 antibody (ab87547)
Key features and details
- Rabbit polyclonal to HRG beta 1
- Suitable for: IHC-P, Sandwich ELISA, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-HRG beta 1 antibody -
Description
Rabbit polyclonal to HRG beta 1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, Sandwich ELISA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant Human HRG beta 1.
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General notes
Although some customers have been successful in IHC we no longer batch test in this application.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab87547 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use at an assay dependent concentration.
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Sandwich ELISA |
Use at an assay dependent concentration.
Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1. Can be used as capture antibody when paired with ab87549. |
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WB | (1) |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1. Can be used as capture antibody when paired with ab87549. |
WB
Use at an assay dependent concentration. |
Target
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Relevance
HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF). -
Cellular localization
Secreted -
Database links
- Entrez Gene: 3084 Human
- Omim: 142445 Human
- SwissProt: Q02297 Human
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Alternative names
- Acetylcholine receptor inducing activity antibody
- ARIA antibody
- Breast cancer cell differentiation factor p45 antibody
see all
Datasheets and documents
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Datasheet download
References (1)
ab87547 has been referenced in 1 publication.
- Jiao L et al. Nuclear factor-kappa B activation inhibits proliferation and promotes apoptosis of vascular smooth muscle cells. Vascular 26:634-640 (2018). PubMed: 30003828