Harmine, DYRK1A inhibitor (ab120225)
Key features and details
- Potent and selective inhibitor of DYRK1A
- CAS Number: 442-51-3
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Harmine, DYRK1A inhibitor -
Description
Potent and selective inhibitor of DYRK1A -
Biological description
Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
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CAS Number
442-51-3 -
Chemical structure
Properties
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Chemical name
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole -
Molecular weight
212.25 -
Molecular formula
C13H12N2O -
PubChem identifier
5280953 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc3c(c1)nc2c3ccnc2C -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120225 has been referenced in 2 publications.
- Kim MJ et al. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell 81:1698-1714.e6 (2021). PubMed: 33626321
- Yamamoto T et al. Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett 591:842-853 (2017). PubMed: 28194753