Overview

  • Product name
    IEM-1460
  • Description
    Selective GluR2 lacking AMPA receptor blocker. Open channel blocker.
  • Biological description
    Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.

    Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.

Properties

References

This product has been referenced in:
  • Schlesinger F  et al. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br J Pharmacol 145:656-63 (2005). Read more (PubMed: 15834439) »
  • Buldakova SL  et al. Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460. Brain Res 846:52-8 (1999). Read more (PubMed: 10536213) »
  • Magazanik LG  et al. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J Physiol 505 ( Pt 3):655-63 (1997). Read more (PubMed: 9457643) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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