Key features and details
- Rat monoclonal [RM0100-3J42] to IGF2
- Suitable for: Sandwich ELISA
- Reacts with: Rat
- Isotype: IgG2
Product nameAnti-IGF2 antibody [RM0100-3J42]
See all IGF2 primary antibodies
DescriptionRat monoclonal [RM0100-3J42] to IGF2
Tested applicationsSuitable for: Sandwich ELISAmore details
Species reactivityReacts with: Rat
Recombinant full length Mouse protein
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
Purification notesThe IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and 0.2µm filtered.
sELISA pair antibody
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab86485 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionThe insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Involvement in diseaseEpigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
Sequence similaritiesBelongs to the insulin family.
modificationsO-glycosylated with a core 1 or possibly core 8 glycan.
- Information by UniProt
- C11orf43 antibody
- IGF 2 antibody
- IGF II antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab86485 has not yet been referenced specifically in any publications.