Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490)
Key features and details
- Prototypic kainate receptor agonist. 1 ml water soluble pack.
- CAS Number: 487-79-6
- Purity: > 99%
- Soluble in 1ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Digenea simplex
Overview
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Product name
Kainic acid (mM/ml), Prototypic kainate receptor agonist -
Description
Prototypic kainate receptor agonist. 1 ml water soluble pack. -
Alternative names
- Kainate
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Biological description
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
Purity
> 99% -
CAS Number
487-79-6 -
Chemical structure
Properties
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Chemical name
(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid -
Molecular weight
213.23 -
Molecular formula
C10H15NO4 -
PubChem identifier
10255 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1ml of water to give specified mM/ml concentration -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
Source
Digenea simplex
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Research areas
Images
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2D chemical structure image of ab144490, Kainic acid (mM/ml), Prototypic kainate receptor agonist
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Immunocytochemistry/ Immunofluorescence analysis of microglial cells in the stratum radiatum of the CA1 region of the hippocampus of CX3CR1egfp/+ mice in control conditions (left) or 48 hours after status epilepticus (SE) induced by intra-peritoneal injection of kainate (right). Each image is a maximum intensity z-projection of 31 confocal slices for a total thickness of 12 µm.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (34)
ab144490 has been referenced in 34 publications.
- Henry KS & Abrams KS Normal Tone-In-Noise Sensitivity in Trained Budgerigars despite Substantial Auditory-Nerve Injury: No Evidence of Hidden Hearing Loss. J Neurosci 41:118-129 (2021). PubMed: 33177067
- Taga A et al. Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. J Vis Exp N/A:N/A (2021). PubMed: 34515684
- Wong SJ et al. Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar. Hear Res 374:24-34 (2019). PubMed: 30703625
- Tischbein M et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem 294:10194-10210 (2019). PubMed: 31092554
- Shi C et al. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Front Mol Neurosci 11:5 (2018). PubMed: 29416502