Soluble guanylate cyclase inhibitor (IC50 = 2 μM). Competitive NADPH inhibitor (Ki = 2 μM). Noncompetitive glutathione reductase inhibitor (Ki = 3 μM). Inhibits leukotriene synthesis (IC50 = 1.8 μM). Selective MPS1 protein kinase inhibitor. Induces p21. Lowers cGMP and cAMP levels in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in ethanol to 10 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.