Overview

  • Product name
    LY83583
  • Description
    Soluble guanylate cyclase inhibitor
  • Biological description
    Soluble guanylate cyclase inhibitor (IC50 = 2 μM). Competitive NADPH inhibitor (Ki = 2 μM). Noncompetitive glutathione reductase inhibitor (Ki = 3 μM). Inhibits leukotriene synthesis (IC50 = 1.8 μM). Selective MPS1 protein kinase inhibitor. Induces p21. Lowers cGMP and cAMP levels in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Tsuda K  et al. Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase. Biochem Biophys Res Commun 409:418-23 (2011). Read more (PubMed: 21586273) »
  • Lodygin D  et al. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest 110:1717-27 (2002). Read more (PubMed: 12464677) »
  • Kontos HA & Wei EP Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke 24:427-34 (1993). Read more (PubMed: 8095358) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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