β-carboline alkaloid. GSK-3β inhibitor. Inhibits growth of rodent malaria parasite in vivo. Inhibits autophagy in pancreatic cancer cells. Orally active. Antimalarial, neuroprotective and anticancer agent. Active in vivo and in vitro.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kallifatidis G et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs11:3500-16 (2013).
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Hamann M et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod70:1397-405 (2007).
Read more (PubMed: 17708655) »
Ang KK et al. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrob Agents Chemother44:1645-9 (2000).
Read more (PubMed: 10817722) »