Anti-Metabotropic Glutamate Receptor 7/MGLUR7 antibody (ab53705)
Key features and details
- Rabbit polyclonal to Metabotropic Glutamate Receptor 7/MGLUR7
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Metabotropic Glutamate Receptor 7/MGLUR7 antibody
See all Metabotropic Glutamate Receptor 7/MGLUR7 primary antibodies -
Description
Rabbit polyclonal to Metabotropic Glutamate Receptor 7/MGLUR7 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human Metabotropic Glutamate Receptor 7/MGLUR7.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53705 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa).
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IHC-P | (1) |
Use at an assay dependent concentration.
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa). |
IHC-P
Use at an assay dependent concentration. |
Target
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Function
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. -
Tissue specificity
Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. -
Sequence similarities
Belongs to the G-protein coupled receptor 3 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2917 Human
- Entrez Gene: 108073 Mouse
- Entrez Gene: 81672 Rat
- Omim: 604101 Human
- SwissProt: Q14831 Human
- SwissProt: Q68ED2 Mouse
- SwissProt: P35400 Rat
- Unigene: 606393 Human
see all -
Alternative names
- FLJ40498 antibody
- GLUR7 antibody
- Glutamate receptor metabotropic 7 antibody
see all
Images
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All lanes : Anti-Metabotropic Glutamate Receptor 7/MGLUR7 antibody (ab53705) at 1/500 dilution
Lane 1 : HuvEc cell extract
Lane 2 : HuvEc cell extract with immunising peptide
Predicted band size: 102 kDa
Observed band size: 102 kDa -
ab53705 at 1/50 dilution staining Metabotropic Glutamate Receptor 7/MGLUR7 in human brain by Immunohistochemsitry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab53705 has been referenced in 2 publications.
- Habrian CH et al. Conformational pathway provides unique sensitivity to a synaptic mGluR. Nat Commun 10:5572 (2019). PubMed: 31804469
- Wang H et al. Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain. Neuroreport 22:244-8 (2011). PubMed: 21358553