Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Mexiletine hydrochloride inhibits NaV1.4 channels heterologously expressed in Xenopus oocytes.
A. Time course of Nav1.4 current amplitude changes as a result of 1 mM Mexiletine hydrochloride (ab141823) application (marked by the horizontal bar), for each of the two test pulses. B. Currents were elicited by a double test pulse protocol applied every 10 sec, which is schematically described on the top panel. For the first pulse the holding potential is -120 mV while the second pulse is preceded by 300 ms at 60 mV. On the bottom; superimposed example current responses to the voltage stimulation, before (black) and during application of 1 mM Mexiletine hydrochloride (green).
This product has been referenced in:
Tzanavaras PD et al. Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution. J Pharm Biomed Anal48:1254-60 (2008).
Read more (PubMed: 18930618) »
Pietras R et al. Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation. J AOAC Int93:820-4 (0).
Read more (PubMed: 20629382) »
Belal TS et al. Selective and stability-indicating methods for the simultaneous determination of mexiletine hydrochloride and/or its related substance: 2,6-dimethylphenol. J AOAC Int91:720-30 (0).
Read more (PubMed: 18727529) »