Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor (ab141041)
Key features and details
- Type II topoisomerase inhibitor
- CAS Number: 70476-82-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor -
Description
Type II topoisomerase inhibitor -
Biological description
Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.
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Purity
> 98% -
CAS Number
70476-82-3 -
Chemical structure
Properties
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Chemical name
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride -
Molecular weight
517.41 -
Molecular formula
C22H28N4O6.2HCl -
PubChem identifier
51082 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.OCCNCCNc3ccc(NCCNCCO)c2C(=O)c1c(O)ccc(O)c1C(=O)c23 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab141041 has been referenced in 1 publication.
- Szymanska E et al. Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. EMBO Mol Med 12:e10812 (2020). PubMed: 31930723