Anti-NR0B2 antibody (ab96605)
Key features and details
- Rabbit polyclonal to NR0B2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NR0B2 antibody
See all NR0B2 primary antibodies -
Description
Rabbit polyclonal to NR0B2 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment, corresponding to a region within the internal sequence amino acids 64-246 of Human NR0B2.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab96605 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 28 kDa.
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IHC-P |
1/100 - 1/250.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 28 kDa. |
IHC-P
1/100 - 1/250. |
Target
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Function
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. -
Tissue specificity
Liver. Low levels of expression were detected in heart and pancreas. -
Involvement in disease
Obesity -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR0 subfamily. -
Post-translational
modificationsArginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. -
Cellular localization
Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus. - Information by UniProt
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Database links
- Entrez Gene: 8431 Human
- Omim: 604630 Human
- SwissProt: Q15466 Human
- Unigene: 427055 Human
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Alternative names
- NR0B2 antibody
- NR0B2_HUMAN antibody
- Nr0b2a antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab96605 has been referenced in 3 publications.
- Chen SW et al. Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish. Int J Mol Sci 22:N/A (2021). PubMed: 34769475
- Gallo-Ebert C et al. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 293:5956-5974 (2018). PubMed: 29491146
- Prestin K et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther 9:4867-78 (2016). WB ; Human . PubMed: 27540300