Product nameOkadaic acid, PP1 and PP2A inhibitor
DescriptionPP1 and PP2A inhibitor
Biological descriptionPotent inhibitor of protein phosphatase 1 (IC50 = 3 - 15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Highly selective over PP2B, PP2C and a range of other phosphatases. Tumor promotor.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120375 has been referenced in 8 publications.
- Zhu Y et al. a- and ß-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med 13:1143-1150 (2017). PubMed: 28450955
- Musante V et al. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Elife 6:N/A (2017). PubMed: 28613156
- Hu XK et al. Liraglutide attenuates the osteoblastic differentiation of MC3T3-E1 cells by modulating AMPK/mTOR signaling. Mol Med Rep 14:3662-8 (2016). PubMed: 27600753
- Ahmed T et al. Rescue of impaired late-phase long-term depression in a tau transgenic mouse model. Neurobiol Aging 36:730-9 (2015). PubMed: 25443285
- Carr L et al. Calcineurin activity assay measurement by liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring mode. Clin Chem 60:353-60 (2014). PubMed: 24281780
- Chiang HS et al. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol 15:63-71 (2014). PubMed: 24270516
- Kunz PA et al. Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release. J Neurosci 33:7762-9 (2013). PubMed: 23637168
- Ransdell JL et al. Rapid homeostatic plasticity of intrinsic excitability in a central pattern generator network stabilizes functional neural network output. J Neurosci 32:9649-58 (2012). PubMed: 22787050