Anti-LPA-4 antibody (ab115454)
Key features and details
- Rabbit polyclonal to LPA-4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-LPA-4 antibody
See all LPA-4 primary antibodies -
Description
Rabbit polyclonal to LPA-4 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Hamster, Gorilla, Common marmoset, Bat -
Immunogen
Synthetic peptide corresponding to Human LPA-4 (C terminal) conjugated to keyhole limpet haemocyanin.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.4
Preservative: 0.01% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab115454 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. -
Tissue specificity
High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2846 Human
- Entrez Gene: 78134 Mouse
- Entrez Gene: 302378 Rat
- Omim: 300086 Human
- SwissProt: Q99677 Human
- SwissProt: Q8BLG2 Mouse
- Unigene: 522701 Human
- Unigene: 90147 Mouse
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Alternative names
- 5730485F04Rik antibody
- G protein coupled receptor 23 antibody
- G-protein coupled receptor 23 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab115454 has been referenced in 1 publication.
- Feng Y & Liu JF Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Exp Ther Med 7:423-428 (2014). WB ; Human . PubMed: 24396418