Anti-PRKACG antibody [EP2647Y] (ab108385)
Key features and details
- Rabbit monoclonal [EP2647Y] to PRKACG
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Related conjugates and formulations
Overview
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Product name
Anti-PRKACG antibody [EP2647Y]
See all PRKACG primary antibodies -
Description
Rabbit monoclonal [EP2647Y] to PRKACG -
Host species
Rabbit -
Specificity
This antibody is likely to react with the alpha subunit, as it possesses 85.7% similar homology with the immunogen. Additionally, it may react with the beta subunit, possessing 78.6% homology.
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Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF or IHC-P -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- HeLa, MCF7, PC3 and A549 cell lysates
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General notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EP2647Y -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab108385 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/50000 - 1/200000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
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Notes |
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WB
1/50000 - 1/200000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa). |
Target
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Function
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. -
Tissue specificity
Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. -
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain. - Information by UniProt
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Database links
- Entrez Gene: 5568 Human
- Omim: 176893 Human
- SwissProt: P22612 Human
- Unigene: 158029 Human
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Alternative names
- cAMP-dependent protein kinase catalytic subunit gamma antibody
- KAPCG_HUMAN antibody
- KAPG antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab108385 has been referenced in 7 publications.
- Song C et al. Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota. Commun Biol 5:680 (2022). PubMed: 35804021
- Ye J et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2a elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell 19:e13055 (2020). PubMed: 31668016
- Reis MB et al. Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. Nat Commun 11:5433 (2020). PubMed: 33116136
- Yin C et al. PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation. PLoS One 14:e0214606 (2019). PubMed: 30990811
- Cao W et al. Hoxa5 Promotes Adipose Differentiation via Increasing DNA Methylation Level and Inhibiting PKA/HSL Signal Pathway in Mice. Cell Physiol Biochem 45:1023-1033 (2018). PubMed: 29439250
- Liu G et al. ColXV promotes adipocyte differentiation via inhibiting DNA methylation and cAMP/PKA pathway in mice. Oncotarget 8:60135-60148 (2017). PubMed: 28947959
- Cao N et al. Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis. Cell Death Dis 8:e2996 (2017). WB . PubMed: 28796260