• Product name

  • Description

    Rabbit polyclonal to PLCZ1
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 322-572 of Human PLCZ1 (BC125067).

  • Positive control

    • HeLa cell, Human fetal liver and fetal kidney lysates, Human fetal testis tissue



Our Abpromise guarantee covers the use of ab124446 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 70 kDa.
IHC-P 1/100 - 1/500.


  • Function

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
  • Tissue specificity

    Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
  • Sequence similarities

    Contains 1 C2 domain.
    Contains 1 EF-hand domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
  • Domain

    The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
    The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
  • Cellular localization

    Nucleus. Cytoplasm > perinuclear region. Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase zeta 1 antibody
    • 1-phosphatidylinositol-4 antibody
    • 5-bisphosphate phosphodiesterase zeta-1 antibody
    • MGC149685 antibody
    • NYD SP27 antibody
    • Phosphoinositide phospholipase C zeta 1 antibody
    • Phosphoinositide phospholipase C-zeta-1 antibody
    • Phospholipase C zeta 1 antibody
    • Phospholipase C-zeta-1 antibody
    • PI phospholipase C zeta 1 antibody
    • PLC zeta 1 antibody
    • PLC-zeta-1 antibody
    • PLCZ1 antibody
    • PLCZ1_HUMAN antibody
    • PLCzeta antibody
    • Testis development protein NYD SP27 antibody
    • Testis development related NYD SP27 antibody
    • Testis-development protein NYD-SP27 antibody
    see all


  • ab124446 at 1/100 dilution staining PLCZ1 in Human fetal testis tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.


This product has been referenced in:

  • Nakasuji T  et al. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. PLoS Genet 13:e1006578 (2017). WB . Read more (PubMed: 28114340) »
See 1 Publication for this product

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