Prostaglandin J2, PGD2 analog (ab120913)
Key features and details
- Endogenous product of inflammation; PGD2 analog
- CAS Number: 60203-57-8
- Purity: > 95%
- Supplied in methyl acetate (5 mg/ml)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Prostaglandin J2, PGD2 analog -
Description
Endogenous product of inflammation; PGD2 analog -
Alternative names
- PGJ2
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Purity
> 95% -
CAS Number
60203-57-8 -
Chemical structure
Properties
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Chemical name
(5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid -
Molecular weight
334.45 -
Molecular formula
C20H30O4 -
Storage instructions
Store at -80°C. -
Solubility overview
Supplied in methyl acetate (5 mg/ml) -
Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCC(O)/C=C/[C@@H]1C(C/C=CCCCC(=O)O)C=CC1=O -
Source
Synthetic
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Research areas
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab120913 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Functional Studies |
Use at an assay dependent concentration.
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Notes |
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Functional Studies
Use at an assay dependent concentration. |
Images
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2D chemical structure image of ab120913, Prostaglandin J2, PGD2 analog
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ab80579 staining tau in SKNSH cells treated with prostaglandin J2 (ab120913), by ICC/IF. Expression of tau expression is restringed to the perinuclear zone with increased concentration of prostaglandin J2, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120913 (prostaglandin J2) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab80579 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei (blue) were counterstained with DAPI and membrane is was stained using WGA (red).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab120913 has not yet been referenced specifically in any publications.