QX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker (ab120118)
Key features and details
- Na+ channel blocker
- CAS Number: 5369-03-9
- Soluble in water to 100 mM and to 50 mM in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
QX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker -
Description
Na+ channel blocker -
Alternative names
- N-Ethyllidocaine chloride
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Biological description
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.
Also available in simple stock solutions (ab144493) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
5369-03-9 -
Chemical structure
Properties
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Chemical name
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride -
Molecular weight
298.85 -
Molecular formula
C16H27ClN2O -
PubChem identifier
21462 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and to 50 mM in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (15)
ab120118 has been referenced in 15 publications.
- Biane C et al. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. Elife 10:N/A (2021). PubMed: 34730085
- Weyrer C et al. Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse. Cell Rep 36:109719 (2021). PubMed: 34551307
- Vaden RJ et al. Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells. Elife 9:N/A (2020). PubMed: 32602839
- Rudolph S et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
- Hoehne A et al. Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex. Elife 9:N/A (2020). PubMed: 32990593