Anti-RILP antibody (ab140188)
Key features and details
- Rabbit polyclonal to RILP
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-RILP antibody -
Description
Rabbit polyclonal to RILP -
Host species
Rabbit -
Specificity
At least two isoforms of RILP are known to exist; ab140188 will only detect the longer isoform. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
An 18 amino acid synthetic peptide near the center of Human RILP.
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Positive control
- A20 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab140188 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. |
Target
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Function
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. -
Tissue specificity
Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain. -
Sequence similarities
Contains 1 RILP-like domain. -
Cellular localization
Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle > phagosome membrane. Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. - Information by UniProt
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Database links
- Entrez Gene: 280408 Mouse
- SwissProt: Q5ND29 Mouse
- Unigene: 41416 Mouse
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Alternative names
- FLJ31193 antibody
- PP10141 antibody
- Rab interacting lysosomal protein antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (5)
ab140188 has been referenced in 5 publications.
- Zhang Y et al. Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLoS Genet 18:e1010232 (2022). PubMed: 35727824
- Napolitano F et al. Rare Variants in Autophagy and Non-Autophagy Genes in Late-Onset Pompe Disease: Suggestions of Their Disease-Modifying Role in Two Italian Families. Int J Mol Sci 22:N/A (2021). PubMed: 33807278
- Cason SE et al. Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. J Cell Biol 220:N/A (2021). PubMed: 34014261
- Zhao Y et al. Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aß Clearance. Front Aging Neurosci 12:47 (2020). PubMed: 32210783
- Sarkar C et al. Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis. J Inherit Metab Dis 43:1082-1101 (2020). PubMed: 32279353