Recombinant Human CLEC-2 protein (denatured) (ab202622)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
Description
-
Product name
Recombinant Human CLEC-2 protein (denatured)
See all CLEC-2 proteins and peptides -
Purity
> 90 % SDS-PAGE.
ab202622 was purified by conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Sequence
MGSSHHHHHH SSGLVPRGSH MGSSVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP -
Predicted molecular weight
23 kDa including tags -
Amino acids
55 to 229 -
Tags
His tag N-Terminus -
Additional sequence information
NP_057593
-
Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab202622 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
-
Form
Liquid -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 10% Glycerol (glycerin, glycerine), 0.24% Tris buffer
General Info
-
Alternative names
- 1810061I13Rik
- C type lectin domain family 1 member B
- C type lectin like receptor 2
see all -
Function
Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. -
Tissue specificity
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. -
Sequence similarities
Contains 1 C-type lectin domain. -
Post-translational
modificationsGlycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding. -
Cellular localization
Membrane. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab202622 has not yet been referenced specifically in any publications.