Recombinant Human Chromogranin A protein (ab85339)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVME
    • Amino acids
      19 to 131
    • Additional sequence information
      This fragment is from the N terminus of Chromogranin A.

Specifications

Our Abpromise guarantee covers the use of ab85339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    ab85339 is purified using conventional chromatography techniques. Endotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method).
  • Form
    Liquid
  • Additional notes


    Vasostatin 2 is the N-terminal fragment (19-131 aa) derived from the cleavage of chromogranin A (CgA) which is a member of the chromogranin/secretogranin(granins) family of neuroendocrine secretory proteins. Vasostatin 2 has been shown to exert several biological activities on several tissues and organs and exerts a large spectrum of homeostatic actions, including antifungal and antimicrobial effect, modulation of cell adhesion, and inhibition of parathyroid hormone secretion.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.316% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • beta Granin
    • betagranin (N-terminal fragment of chromogranin A)
    • catestatin
    • CgA
    • CHG A
    • Chga
    • chromofungin
    • Chromogranin A
    • Chromogranin A parathyroid secretory protein 1
    • Chromogranin A precursor
    • ChromograninA
    • CMGA_HUMAN
    • ER-37
    • Pancreastatin
    • Parastatin
    • Parathyroid secretory protein 1
    • Pituitary secretory protein I
    • Secretory protein I
    • SP I
    • SP-I
    • SP1
    • SPI
    • Vasostatin
    • vasostatin 2
    • Vasostatin I
    • Vasostatin II
    • vasostatin-2
    see all
  • Function
    Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
  • Sequence similarities
    Belongs to the chromogranin/secretogranin protein family.
  • Post-translational
    modifications
    Sulfated on tyrosine residues and/or contains sulfated glycans.
    O-glycosylated with core 1 or possibly core 8 glycans.
  • Cellular localization
    Secreted. Neuroendocrine and endocrine secretory granules.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab85339 at approximately 12.8kDa (3µg).

References

ab85339 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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