Recombinant Human HEC1/HEC protein (ab131907)
Key features and details
- Expression system: Wheat germ
- Suitable for: WB, SDS-PAGE, ELISA
Description
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Product name
Recombinant Human HEC1/HEC protein -
Expression system
Wheat germ -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTS ERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLC EFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEE VPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKE SSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAEL QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENT RLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELK YARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCL VKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSV RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGL SEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE -
Predicted molecular weight
100 kDa including tags -
Amino acids
1 to 642
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab131907 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
SDS-PAGE
ELISA
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Form
Liquid -
Additional notes
This product was previously labelled as HEC1.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- from Entrez Gene ;
- HEC
- Highly expressed in cancer
see all -
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. -
Sequence similarities
Belongs to the NDC80/HEC1 family. -
Developmental stage
Expression peaks in mitosis. -
Post-translational
modificationsPhosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB. -
Cellular localization
Nucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab131907 has not yet been referenced specifically in any publications.