Product nameRecombinant Human HP1 gamma protein
See all HP1 gamma proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ
Molecular weight23 kDa including tags
Amino acids1 to 183
TagsHis tag N-Terminus
- Anti-HP1 gamma antibody (ab10480)
- Anti-6X His tag® antibody (ab14923)
- Anti-6X His tag® antibody [AD1.1.10] (ab15149)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-HP1 gamma antibody (ab40827)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-HP1 gamma antibody (ab66617)
- Anti-6X His tag® antibody (ab9136)
Our Abpromise guarantee covers the use of ab124548 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 90 % SDS-PAGE.
Purified by using conventional chromatography.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride
- CBX 3
FunctionSeems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Sequence similaritiesContains 2 chromo domains.
modificationsPhosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Cellular localizationNucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
- Information by UniProt
ab124548 has not yet been referenced specifically in any publications.