Recombinant Human TPH2 protein (ab173061)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Tags: His tag N-Terminus
- Suitable for: HPLC, SDS-PAGE
Description
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Product name
Recombinant Human TPH2 protein
See all TPH2 proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab173061 is greater than 95% pure, as determined by SEC-HPLC and reducing SDS-PAGE. It is supplied as an 0.2 µM filtered solution. -
Endotoxin level
< 1.000 Eu/µg -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTASTFLKLNKPNSGKN DDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHI ESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTE EEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYF VDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFP LLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYR VFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASL GASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDK ACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFS VYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGIVDLQ SR -
Predicted molecular weight
59 kDa including tags -
Amino acids
1 to 490 -
Tags
His tag N-Terminus -
Additional sequence information
N terminal His tag sequence: MNHKVHHHHHH.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab173061 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituent: 100% PBS
General Info
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Alternative names
- MGC138871
- ADHD7
- FLJ37295
see all -
Tissue specificity
Brain specific. -
Pathway
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. -
Involvement in disease
Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. -
Sequence similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab173061 has not yet been referenced specifically in any publications.