Anti-SGLT2 antibody (ab37296)
Key features and details
- Rabbit polyclonal to SGLT2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-SGLT2 antibody
See all SGLT2 primary antibodies -
Description
Rabbit polyclonal to SGLT2 -
Host species
Rabbit -
Specificity
The antibody detects 74 kDa SGLT-2 from human, mouse, and rat origins. Reactivity to other species has not been determined. A ~55 kDa and a ~45 kDa band can also be detected, representing the SGLT-2 cleavage fragments. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Mouse SGLT2 (N terminal).
Database link: Q923I7 -
Positive control
- WB: Jurkat, NIH3T3, PC12
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General notes
This product is manufactured by BioVision, an Abcam company and was previously called 3690 SGLT-2 Antibody. 3690-100 is the same size as the 100 µg size of ab37296.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 1% BSA, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab37296 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (8) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. |
Target
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Function
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. -
Involvement in disease
Defects in SLC5A2 are the cause of renal glucosuria (GLYS1) [MIM:233100]. GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. -
Sequence similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 6524 Human
- Entrez Gene: 246787 Mouse
- Entrez Gene: 64522 Rat
- Omim: 182381 Human
- SwissProt: P31639 Human
- SwissProt: Q923I7 Mouse
- SwissProt: P53792 Rat
- Unigene: 709195 Human
see all -
Alternative names
- Low affinity sodium glucose cotransporter antibody
- Low affinity sodium-glucose cotransporter antibody
- Na(+) glucose cotransporter 2 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (34)
ab37296 has been referenced in 34 publications.
- Korfhage J et al. Canagliflozin Increases Intestinal Adenoma Burden in Female ApcMin/+ Mice. J Gerontol A Biol Sci Med Sci 77:215-220 (2022). PubMed: 34448851
- Xu Z et al. Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy. Yonsei Med J 63:619-631 (2022). PubMed: 35748073
- Li SR et al. Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease. Nat Commun 13:7918 (2022). PubMed: 36564419
- Bernhardt A et al. High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1. FASEB J 35:e21912 (2021). PubMed: 34533842
- Liu SH et al. Chitosan Oligosaccharide Alleviates Abnormal Glucose Metabolism without Inhibition of Hepatic Lipid Accumulation in a High-Fat Diet/Streptozotocin-Induced Diabetic Rat Model. Mar Drugs 19:N/A (2021). PubMed: 34201848