Anti-SLC40A1 antibody (ab58695)
Key features and details
- Rabbit polyclonal to SLC40A1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SLC40A1 antibody
See all SLC40A1 primary antibodies -
Description
Rabbit polyclonal to SLC40A1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Mouse SLC40A1 (N terminal).
Sequence:LKQLTSPKDTEPKPLEGT
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab58695 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 1 µg/ml. Detects a band of approximately 69 kDa (predicted molecular weight: 62-69 kDa).
Incubate for 2hrs |
Notes |
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WB
Use a concentration of 1 µg/ml. Detects a band of approximately 69 kDa (predicted molecular weight: 62-69 kDa). Incubate for 2hrs |
Target
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Function
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). -
Tissue specificity
Expressed in placenta, intestine, muscle and spleen. -
Involvement in disease
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. -
Sequence similarities
Belongs to the SLC40A transporter family. -
Cellular localization
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells. - Information by UniProt
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Database links
- Entrez Gene: 30061 Human
- Entrez Gene: 53945 Mouse
- Omim: 604653 Human
- SwissProt: Q9NP59 Human
- SwissProt: Q9JHI9 Mouse
- Unigene: 643005 Human
- Unigene: 28756 Mouse
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Alternative names
- Ferroportin 1 antibody
- Ferroportin antibody
- Ferroportin-1 antibody
see all
Images
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Anti-SLC40A1 antibody (ab58695) at 1 µg/ml + Human colon tissue lysate - total protein (ab30051) at 10 µg
Secondary
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Predicted band size: 62-69 kDa
Observed band size: 62 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (18)
ab58695 has been referenced in 18 publications.
- Zhang M et al. Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice. Cell Death Discov 8:138 (2022). PubMed: 35351859
- Du S et al. Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy. Front Endocrinol (Lausanne) 13:1011669 (2022). PubMed: 36313744
- Zhang M et al. Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis. Front Cell Neurosci 16:1007458 (2022). PubMed: 36467611
- McMillen S & Lönnerdal B Postnatal Iron Supplementation with Ferrous Sulfate vs. Ferrous Bis-Glycinate Chelate: Effects on Iron Metabolism, Growth, and Central Nervous System Development in Sprague Dawley Rat Pups. Nutrients 13:N/A (2021). PubMed: 33921980
- Zhang Y et al. Salvia miltiorrhiza (SM) Injection Ameliorates Iron Overload-Associated Cardiac Dysfunction by Regulating the Expression of DMT1, TfR1, and FP1 in Rats. Evid Based Complement Alternat Med 2021:6864723 (2021). PubMed: 34135983