Overview

  • Product name
  • Description
    Rabbit polyclonal to SOCS6
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Fusion protein corresponding to Human SOCS6 (internal sequence). (BC020082).
    Database link: O14544

  • Positive control
    • Human colon cancer tissue; Jurkat whole cell lysate (ab7899).

Properties

Applications

Our Abpromise guarantee covers the use of ab197335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 60 kDa.

Target

  • Function
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • Domain
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CIS-4 antibody
    • CIS4 antibody
    • Cish4 antibody
    • Cytokine inducible SH2 protein 4 antibody
    • Cytokine-inducible SH2 protein 4 antibody
    • HSPC060 antibody
    • SOCS-4 antibody
    • SOCS-6 antibody
    • SOCS4 antibody
    • Socs6 antibody
    • SOCS6_HUMAN antibody
    • SSI4 antibody
    • STAI4 antibody
    • STAT induced STAT inhibitor 4 antibody
    • STAT4 antibody
    • STATI4 antibody
    • Suppressor of cytokine signaling 4 antibody
    • Suppressor of cytokine signaling 6 antibody
    see all

Images

  • Anti-SOCS6 antibody (ab197335) at 1/600 dilution + Jurkat cell lysate at 40 µg

    Predicted band size: 60 kDa



    10% SDS-PAGE.

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling SOCS6 with ab197335 at 1/35 dilution.

References

This product has been referenced in:
  • Xia Y  et al. miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC. Cell Death Dis 10:112 (2019). Read more (PubMed: 30737371) »
  • Liu Z  et al. Long noncoding RNA neuroblastoma-associated transcript 1 gene inhibits malignant cellular phenotypes of bladder cancer through miR-21/SOCS6 axis. Cell Death Dis 9:1042 (2018). Read more (PubMed: 30310053) »
See all 3 Publications for this product

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