• Product name

  • Description

    Rabbit polyclonal to SRPX2
  • Host species

  • Specificity

    ab91584 is specific for SRPX2 and will not recognize SRPX1
  • Tested applications

    Suitable for: ICC/IF, WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 16 amino acid synthetic peptide from near the amino terminus of Human SRPX2 (NP_055282).

  • Positive control

    • Human lung tissue lysate


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab91584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 53 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.


  • Function

    Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development.
  • Tissue specificity

    Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus and adrenal gland. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines.
  • Involvement in disease

    Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP) [MIM:300388]. BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding.
    Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX) [MIM:300643]. A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
  • Sequence similarities

    Contains 1 HYR domain.
    Contains 3 Sushi (CCP/SCR) domains.
  • Cellular localization

    Cytoplasm. Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • BPP antibody
    • CBPS antibody
    • PMGX antibody
    • RESDX antibody
    • SRPUL antibody
    • SRPX 2 antibody
    • SRPX2 antibody
    • SRPX2_HUMAN antibody
    • Sushi repeat containing protein SRPX2 antibody
    • Sushi repeat containing protein X linked 2 antibody
    • Sushi repeat protein antibody
    • Sushi repeat-containing protein SRPX2 antibody
    see all


  • Lane 1 : Anti-SRPX2 antibody (ab91584) at 1 µg/ml
    Lane 2 : Anti-SRPX2 antibody (ab91584) at 2 µg/ml

    All lanes : Human lung tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 53 kDa

  • Immunofluorescence of SRPX2 in Human lung tissue with ab91584 at 20 ug/mL.

  • Immunohistochemistry of rat lung tissue with ab91584 at 5 μg/mL.


This product has been referenced in:

  • Zhang M  et al. High SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer. Onco Targets Ther 11:3149-3157 (2018). Read more (PubMed: 29881288) »
  • Anwer M  et al. Sushi repeat-containing protein X-linked 2: A novel phylogenetically conserved hypothalamo-pituitary protein. J Comp Neurol 526:1806-1819 (2018). Read more (PubMed: 29663392) »
See all 3 Publications for this product

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