Anti-Scramblase 1 antibody (ab96318)
Key features and details
- Rabbit polyclonal to Scramblase 1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Scramblase 1 antibody
See all Scramblase 1 primary antibodies -
Description
Rabbit polyclonal to Scramblase 1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment, corresponding to a region within N terminal amino acids 1-256 of Human Scramblase 1
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Positive control
- 293T, A431, H1299, HeLa S3, HepG2, Molt-4 cells, MDAMB468 xenograft
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab96318 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 35 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 35 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. -
Tissue specificity
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle. -
Sequence similarities
Belongs to the phospholipid scramblase family. -
Post-translational
modificationsKnown to be palmitoylated at one, yet undefined, site. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 5359 Human
- Omim: 604170 Human
- SwissProt: O15162 Human
- Unigene: 130759 Human
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Alternative names
- Ca(2+) dependent phospholipid scramblase 1 antibody
- Ca(2+)-dependent phospholipid scramblase 1 antibody
- Erythrocyte phospholipid scramblase antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab96318 has been referenced in 1 publication.
- Berghold VM et al. Phospholipid scramblase 1 (PLSCR1) in villous trophoblast of the human placenta. Histochem Cell Biol 143:381-96 (2015). PubMed: 25362260