Simvastatin, HMG-CoA reductase inhibitor (ab120505)
Key features and details
- HMG-CoA reductase inhibitor
- CAS Number: 79902-63-9
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Simvastatin, HMG-CoA reductase inhibitor -
Description
HMG-CoA reductase inhibitor -
Biological description
HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anticancer and anti-inflammatory properties.
-
CAS Number
79902-63-9 -
Chemical structure
Properties
-
Chemical name
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2,2-dimethyl butanoate -
Molecular weight
418.57 -
Molecular formula
C25H38O5 -
PubChem identifier
54454 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(C)(CC)C(=O)O[C@H]2C[C@@H](C)C=C3C=C[C@H](C)[C@H](CC[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]23 -
Source
Synthetic
-
Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Lipid signaling
- HMG-CoA reductase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Lipid signaling
- HMG-CoA reductase
- Inhibitors
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab120505 has been referenced in 5 publications.
- Denys A et al. Binge Ethanol Exposure in Mice Represses Expression of Genes Involved in Osteoblast Function and Induces Expression of Genes Involved in Osteoclast Differentiation Independently of Endogenous Catalase. Toxicol Sci 185:232-245 (2022). PubMed: 34755883
- Dai B et al. Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss. Bioact Mater 6:2511-2522 (2021). PubMed: 33665494
- Peng Y et al. Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma. J Cancer 8:1655-1664 (2017). PubMed: 28775785
- Paškeviciute M & Petrikaite V Differences of statin activity in 2D and 3D pancreatic cancer cell cultures. Drug Des Devel Ther 11:3273-3280 (2017). PubMed: 29180851
- Wang KC et al. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A 113:11525-11530 (2016). PubMed: 27671657