Anti-Thymosin beta 4 antibody (ab14334)
Key features and details
- Rabbit polyclonal to Thymosin beta 4
- Suitable for: ELISA, IHC-P, ICC, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Thymosin beta 4 antibody
See all Thymosin beta 4 primary antibodies -
Description
Rabbit polyclonal to Thymosin beta 4 -
Host species
Rabbit -
Specificity
Recognises a synthetic Human Thymosin beta 4 peptide(aa 1-43). The antibody has not been tested on the endogenous protein.ab14334 also detects Thymosin beta 9 and Thymosin beta 10 along with Thymosin beta 4. -
Tested applications
Suitable for: ELISA, IHC-P, ICC, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Horse, Chicken, Cow -
Immunogen
Synthetic peptide: SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES conjugated to KLH, corresponding to amino acids 1-43 of Human Thymosin beta 4
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Positive control
- Thymosin beta 4 synthetic peptide
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab14334 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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ICC |
Use at an assay dependent concentration.
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WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 5 kDa.
See Smart et al. Non specific bands were reported by the researcher who published this reference. |
Notes |
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ELISA
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
ICC
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 5 kDa. See Smart et al. Non specific bands were reported by the researcher who published this reference. |
Target
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Function
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase. -
Tissue specificity
Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. -
Sequence similarities
Belongs to the thymosin beta family. -
Cellular localization
Cytoplasm > cytoskeleton. - Information by UniProt
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Database links
- Entrez Gene: 282386 Cow
- Entrez Gene: 100034015 Horse
- Entrez Gene: 7114 Human
- Entrez Gene: 19241 Mouse
- Entrez Gene: 81814 Rat
- Omim: 300159 Human
- SwissProt: P62327 Horse
- SwissProt: P62328 Human
see all -
Alternative names
- Fx antibody
- Hematopoietic system regulatory peptide antibody
- Prothymosin beta 4 antibody
see all
Datasheets and documents
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Datasheet download
References (7)
ab14334 has been referenced in 7 publications.
- Tang S et al. TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair. Front Cell Dev Biol 9:670913 (2021). PubMed: 34178995
- Coni P et al. Thymosin β4 cytoplasmic/nuclear translocation as a new marker of cellular stress. A Caco2 case study. RSC Adv 10:12680-12688 (2020). PubMed: 35497634
- Li X et al. Generation of Tß4 knock-in Cashmere goat using CRISPR/Cas9. Int J Biol Sci 15:1743-1754 (2019). PubMed: 31360116
- Hasan AA et al. Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy. Kidney Int 95:1373-1388 (2019). PubMed: 30979564
- Li H et al. Thymosin β4 suppresses CCl4 -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II. J Gene Med 20:e3043 (2018). PubMed: 29972714
- Kannan L et al. Identification and characterization of thymosin beta-4 in chicken macrophages using whole cell MALDI-TOF. Ann N Y Acad Sci 1112:425-34 (2007). PubMed: 17947593
- Smart N et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature : (2006). PubMed: 17108969