Overview

  • Product name
    Anti-Troponin I fast skeletal muscle antibody
    See all Troponin I fast skeletal muscle primary antibodies
  • Description
    Rabbit polyclonal to Troponin I fast skeletal muscle
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Troponin I fast skeletal muscle.

  • Positive control
    • Human Skeletal Muscle tissue; Human brain lysates

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab134838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/500. Predicted molecular weight: 21 kDa.
ELISA 1/40000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • Involvement in disease
    Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B) [MIM:601680]; also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin.
  • Sequence similarities
    Belongs to the troponin I family.
  • Information by UniProt
  • Database links
  • Alternative names
    • AMCD 2B antibody
    • AMCD2B antibody
    • DA 2B antibody
    • DA2B antibody
    • fast skeletal muscle antibody
    • Fast twitch skeletal muscle troponin I antibody
    • fast-twitch isoform antibody
    • FSSV antibody
    • fsTnI antibody
    • TNNI 2 antibody
    • Tnni2 antibody
    • TNNI2_HUMAN antibody
    • tro antibody
    • Troponin I antibody
    • Troponin I fast skeletal muscle antibody
    • Troponin I fast twitch 2 antibody
    • Troponin I fast twitch isoform antibody
    • Troponin I fast twitch skeletal muscle isoform antibody
    • Troponin I skeletal fast antibody
    • Troponin I type 2 (skeletal fast) antibody
    • Troponin I type 2 antibody
    see all

Images

  • Anti-Troponin I fast skeletal muscle antibody (ab134838) at 1/200 dilution + Human Brain lysate

    Predicted band size: 21 kDa

  • Immunohistochemistry analysis of formalin fixed, paraffin embedded Human Skeletal Muscle tissue labelling Troponin I fast skeletal muscle with ab134838 at 5 µg/ml.

References

This product has been referenced in:
  • Morisasa M  et al. Investigation of the Lipid Changes That Occur in Hypertrophic Muscle due to Fish Protein-feeding Using Mass Spectrometry Imaging. J Oleo Sci 68:141-148 (2019). Read more (PubMed: 30713267) »
  • Ponnusamy S  et al. Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy. Hum Mol Genet 26:2526-2540 (2017). Read more (PubMed: 28453658) »
See all 2 Publications for this product

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