Anti-ULBP2 antibody [MM0593-7F33] (ab89930)
Key features and details
- Mouse monoclonal [MM0593-7F33] to ULBP2
- Suitable for: Flow Cyt, Neutralising
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-ULBP2 antibody [MM0593-7F33]
See all ULBP2 primary antibodies -
Description
Mouse monoclonal [MM0593-7F33] to ULBP2 -
Host species
Mouse -
Tested applications
Suitable for: Flow Cyt, Neutralisingmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant Human ULBP2 protein
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
Clonality
Monoclonal -
Clone number
MM0593-7F33 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab89930 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
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Neutralising |
Use at an assay dependent concentration.
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Notes |
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Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Neutralising
Use at an assay dependent concentration. |
Target
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Function
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. -
Tissue specificity
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. -
Sequence similarities
Belongs to the MHC class I family. -
Cellular localization
Cell membrane. Secreted. - Information by UniProt
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Database links
- Entrez Gene: 80328 Human
- Omim: 605698 Human
- SwissProt: Q9BZM5 Human
- Unigene: 656778 Human
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Alternative names
- ALCAN alpha antibody
- ALCAN-alpha antibody
- N2DL 2 antibody
see all
Datasheets and documents
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Datasheet download
References (3)
ab89930 has been referenced in 3 publications.
- Chitadze G et al. In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment. Oncoimmunology 6:e1358839 (2017). PubMed: 29147621
- Chitadze G et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?d T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology 5:e1093276 (2016). Flow Cyt . PubMed: 27141377
- Fernández L et al. In vitro Natural Killer Cell Immunotherapy for Medulloblastoma. Front Oncol 3:94 (2013). Flow Cyt ; Human . PubMed: 23626949