Anti-USP19 antibody (ab93159)
Key features and details
- Rabbit polyclonal to USP19
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-USP19 antibody
See all USP19 primary antibodies -
Description
Rabbit polyclonal to USP19 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Synthetic peptide derived from an internal region of Human USP19
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab93159 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 145 kDa.
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IHC-P |
1/50 - 1/100.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 145 kDa. |
IHC-P
1/50 - 1/100. |
Target
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Function
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. -
Sequence similarities
Belongs to the peptidase C19 family.
Contains 2 CS domains.
Contains 1 MYND-type zinc finger. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 10869 Human
- Entrez Gene: 71472 Mouse
- Entrez Gene: 361190 Rat
- Omim: 614471 Human
- SwissProt: O94966 Human
- SwissProt: Q3UJD6 Mouse
- SwissProt: Q6J1Y9 Rat
- Unigene: 255596 Human
see all -
Alternative names
- 8430421I07Rik antibody
- AI047774 antibody
- Deubiquitinating enzyme 19 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab93159 has been referenced in 6 publications.
- Zhao X et al. USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy. Autophagy 18:891-908 (2022). PubMed: 34436957
- Hu W et al. Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma. Oncol Rep 43:1964-1974 (2020). PubMed: 32236633
- Gierisch ME et al. USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth. Sci Rep 9:951 (2019). PubMed: 30700749
- Wu X et al. Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nat Commun 10:4115 (2019). PubMed: 31511519
- Lei CQ et al. USP19 Inhibits TNF-a- and IL-1ß-Triggered NF-?B Activation by Deubiquitinating TAK1. J Immunol 203:259-268 (2019). PubMed: 31127032
- Ogawa M et al. 17ß-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor a. J Biol Chem 286:41455-65 (2011). WB ; Mouse . PubMed: 21971047