Product nameAnti-XRCC1 (phospho S461) antibody
See all XRCC1 primary antibodies
DescriptionRabbit polyclonal to XRCC1 (phospho S461)
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region surrounding Serine 461 of Human XRCC1 (P18887)
- Human breast adenocarcinoma; Mouse squamous cell carcinoma.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Purine and pyrimidine synthesis
Our Abpromise guarantee covers the use of ab84413 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionCorrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Sequence similaritiesContains 2 BRCT domains.
modificationsPhosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Cellular localizationNucleus. Accumulates at sites of DNA damage.
- Information by UniProt
- DNA repair protein XRCC1 antibody
- RCC antibody
- X ray repair complementing defective repair in chinese hamster antibody
Immunohistochemistry analysis of two serial sections of formalin-fixed, paraffin-embedded Human breast adenocarcinoma, using 1/250 ab84413 followed by DAB staining. Left panel: mock phosphatase treated; Right panel: calf intestinal phosphatase-treated.
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma, using 1/250 ab84413 followed DAB staining.
ab84413 has not yet been referenced specifically in any publications.