Overview

  • Product name

    A-1155463, BCL-XL inhibitor
  • Description

    Highly potent, selective BCL-XL inhibitor
  • Alternative names

    • A1155463
  • Biological description

    Highly potent, selective BCL-XL inhibitor. Shows picomolar binding affinity to BCL-XL (Ki < 0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki >440 nM).

  • Purity

    > 97%
  • CAS Number

    1235034-55-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid
  • Molecular weight

    669.79
  • Molecular formula

    C35H32FN5O4S2
  • PubChem identifier

    59447577
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Leverson JD  et al. Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. Sci Transl Med 7:279ra40 (2015). Read more (PubMed: 25787766) »
  • Zhang H  et al. Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. Mol Cancer 14:126 (2015). Read more (PubMed: 26134786) »
  • Tao ZF  et al. Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett 5:1088-93 (2014). Read more (PubMed: 25313317) »

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