A 769662, AMP-activated protein kinase activator (ab120335)

Reviews (1)Q&A (1)References (9)

Overview

  • Product name
    A 769662, AMP-activated protein kinase activator
  • Description
    AMP-activated protein kinase activator
  • Biological description
    Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
  • Purity
    > 99%
  • CAS Number
    844499-71-4
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • Molecular weight
    360.39
  • Molecular formula
    C20H12N2O3S
  • PubChem identifier
    54708532
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Oc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Soto-Acosta R  et al. DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. PLoS Pathog 13:e1006257 (2017). Read more (PubMed: 28384260) »
  • Benziane B  et al. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol 297:C1554-66 (2009). Read more (PubMed: 19828836) »
  • Guigas B  et al. Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life 61:18-26 (2009). Read more (PubMed: 18798311) »
  • Göransson O  et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282:32549-60 (2007). Read more (PubMed: 17855357) »
See all 9 Publications for this product

Publishing research using ab120335? Please let us know so that we can cite the reference in this datasheet.

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AMPK

 Excellent
Abreviews
abreview image
AMPK activation in HEK-293 cells. We used a dose on 10uM and 100uM to treat the cells. pAMPK showed a maximal increase at 100uM dose.

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Submitted Sep 05 2018

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