A 769662, AMP-activated protein kinase activator (ab120335)
Key features and details
- AMP-activated protein kinase activator
- CAS Number: 844499-71-4
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
A 769662, AMP-activated protein kinase activator -
Description
AMP-activated protein kinase activator -
Biological description
Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
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CAS Number
844499-71-4 -
Chemical structure
Properties
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Chemical name
6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile -
Molecular weight
360.39 -
Molecular formula
C20H12N2O3S -
PubChem identifier
54708532 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34 -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
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Chemical Structure - A 769662, AMP-activated protein kinase activator (ab120335)2D chemical structure image of ab120335, A 769662, AMP-activated protein kinase activator
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (21)
ab120335 has been referenced in 21 publications.
- Shrikanth CB et al. AMPK differentially alters sulphated glycosaminoglycans under normal and high glucose milieu in proximal tubular cells. J Biochem 169:75-86 (2021). PubMed: 32785657
- Ren Y et al. Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation. Free Radic Biol Med 166:128-139 (2021). PubMed: 33636336
- Gao Y et al. LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. Gastroenterology 158:1389-1401.e10 (2020). PubMed: 31930988
- Qin Y et al. AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression. Mol Oncol 13:1419-1432 (2019). PubMed: 31033201
- Ngoei KRW et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK a2ß2?1 by the Glucose Importagog SC4. Cell Chem Biol 25:728-737.e9 (2018). PubMed: 29657085