Overview

  • Product name

    A 779, angiotensin-(1-7) antagonist
  • Description

    Selective angiotensin-(1-7) antagonist
  • Biological description

    Selective angiotensin-(1-7) antagonist. Shows potent Mas receptor binding affinity (IC50 = 0.3 nM). Antidiuretic and vasoconstrictor agent. Active in vivo and in vitro.
  • Purity

    > 93%
  • CAS Number

    159432-28-7
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    872.98
  • Molecular formula

    C39H60N12O11
  • Sequence

    DRVYIHA (Modifications: Ala-7 = D-Ala)
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xue H  et al. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regul Pept 177:12-20 (2012). Read more (PubMed: 22561449) »
  • Maia LG  et al. Angiotensin-(1-7) antagonist A-779 attenuates the potentiation of bradykinin by captopril in rats. J Cardiovasc Pharmacol 43:685-91 (2004). Read more (PubMed: 15071356) »
  • Santos RA  et al. Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res Bull 35:293-8 (1994). Read more (PubMed: 7850477) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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