Overview

  • Product name

    A 83-01, ALK4, 5 and 7 kinase inhibitor
  • Description

    Potent ALK4, 5 and 7 kinase inhibitor
  • Alternative names

    • A-83-01
    • A83-01
  • Biological description

    Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). Active in vivo and in vitro.

  • Purity

    > 98%
  • CAS Number

    909910-43-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yamamura S  et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer 130:20-8 (2012). Read more (PubMed: 21503873) »
  • Chen WP & Wu SM Small molecule regulators of postnatal Nkx2.5 cardiomyoblast proliferation and differentiation. J Cell Mol Med 16:961-5 (2012). Read more (PubMed: 22212626) »
  • Yuan X  et al. Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells 29:549-53 (2011). Read more (PubMed: 21425417) »

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