Overview

  • Product name

    A 889425, TRPV1 antagonist
  • Description

    Potent, selective TRPV1 antagonist
  • Biological description

    Potent, selective TRPV1 antagonist (IC50 values are 335 and 34 nM for rat and human TRPV1 respectively). Inhibits mechanotransmission in inflamed skin. Shows antinociceptive effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    1072921-02-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(3-Methylpyridin-2-yl)-1-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide
  • Molecular weight

    425.42
  • Molecular formula

    C19H18F3N3O3S
  • PubChem identifier

    76848882
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(N=CC=C1)NC(=O)C2=CCN(CC2)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Schwartz ES  et al. TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci 33:5603-11 (2013). Read more (PubMed: 23536075) »
  • Brederson JD  et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse 66:187-95 (2012). Read more (PubMed: 21953601) »
  • Chu KL  et al. TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain. Brain Res 1369:158-66 (2011). Read more (PubMed: 21047496) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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