Anti-AADAC/DAC antibody (ab214184)

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Overview

  • Product name

    Anti-AADAC/DAC antibody

  • Description

    Rabbit polyclonal to AADAC/DAC

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat

  • Immunogen

    Synthetic peptide within Human AADAC/DAC aa 230-280 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    PSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFK F


    Database link: P22760

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • IHC-P: Human colon carcinoma tissue.

  • General notes

     This product was previously labelled as AADAC

     

Properties

Applications

Our Abpromise guarantee covers the use of ab214184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.

  • Tissue specificity

    Mainly expressed in liver, small intestine, colon and adrenal gland.

  • Sequence similarities

    Belongs to the 'GDXG' lipolytic enzyme family.

  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • AAAD_HUMAN antibody
    • Aada antibody
    • Aadac antibody
    • Arylacetamide deacetylase (esterase) antibody
    • Arylacetamide deacetylase antibody
    • CES5A1 antibody
    • DAC antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AADAC/DAC antibody (ab214184)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AADAC/DAC antibody (ab214184)

    Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human colon carcinoma tissue sections labeling AADAC/DAC using ab214184 at a 1/200 dilution. DAB staining.

References

ab214184 has not yet been referenced specifically in any publications.

Publishing research using ab214184? Please let us know so that we can cite the reference in this datasheet.

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