AANAT peptide (ab5004)

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Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilized

  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AA-NAT, catalog ab3506. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

     This product was previously labelled as Serotonin N-acetyltransferase

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    >95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • AA-NAT
    • Aanat
    • Aralkylamine N-acetyltransferase
    • Arylalkylamine N acetyltransferase
    • Serotonin acetylase
    • Serotonin N-acetyltransferase
    • SNAT
    • SNAT_HUMAN
    see all

  • Function

    Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

  • Tissue specificity

    Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.

  • Pathway

    Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.

  • Involvement in disease

    Delayed sleep phase syndrome

  • Sequence similarities

    Belongs to the acetyltransferase family. AANAT subfamily.
    Contains 1 N-acetyltransferase domain.

  • Post-translational
    modifications

    cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab5004? Please let us know so that we can cite the reference in this datasheet.

ab5004 has not yet been referenced specifically in any publications.

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