Overview

  • Product name

  • Description

    Rabbit polyclonal to AATF/DED
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human AATF/DED aa 150-293.
    Sequence:

    SVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAG DRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALL TTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLTSLVGLQ


    Database link: Q9NY61

  • Positive control

    • IHC-P: Human cerebral cortex tissue.
  • General notes

     This product was previously labelled as AATF

     

Properties

Applications

Our Abpromise guarantee covers the use of ab223780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
  • Tissue specificity

    Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
  • Sequence similarities

    Belongs to the AATF family.
  • Post-translational
    modifications

    Hyperphosphorylated during the G1/S phase transition.
  • Cellular localization

    Nucleus > nucleolus.
  • Information by UniProt
  • Database links

  • Alternative names

    • AATF antibody
    • AATF_HUMAN antibody
    • Apoptosis antagonizing transcription factor antibody
    • Apoptosis-antagonizing transcription factor antibody
    • BFR2 antibody
    • CHE 1 antibody
    • CHE1 antibody
    • DED antibody
    • Protein AATF antibody
    • Rb binding protein Che 1 antibody
    • Rb-binding protein Che-1 antibody
    see all

Images

  • Paraffin-embedded human cerebral cortex tissue stained for AATF/DED using ab223780 at 1/50 dilution in immunohistochemical analysis.

References

ab223780 has not yet been referenced specifically in any publications.

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